Indian markets slipped on September 22 as Sensex fell 435 points and Nifty 50 closed below 25,250. IT and pharma stocks dropped after the US raised one-time H-1B visa fees. Gains in power, oil & gas, and realty were insufficient to offset losses. Top Nifty losers included Tech Mahindra, TCS, Infosys, Cipla while Adani Enterprises, Bajaj finance, Eternal, Ultratech gained.